Fig. 7 | Nature Communications

Fig. 7

From: Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila

Fig. 7

Model of the role of Mrg15 in Ash1 complex. a Wild-type Ash1 stably interacts with Mrg15 and becomes activated to produce adequate amounts of H3K36me2 that antagonizes Polycomb silencing at the common targets of Ash1 and Mrg15. b Ash1R1288A mutation greatly weakens its interaction with Mrg15 and impairs Mrg15-mediated activation, which causes the failure of anti silencing. c Expression of Mrg15-Nurf55 fusion protein partially restores the activation and anti silencing function of Ash1R1288A mutant

Back to article page