Fig. 4 | Nature Communications

Fig. 4

From: The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

Fig. 4

Reduced ISW-1 activity decreases lifespan and the expression of sHSPs. a–c N2 lifespan on isw-1 RNAi according to RNAi regimen a i or b ii or c iii. See Supplementary Table 2 for lifespan statistics. d, e sHSP expression in N2 and isw-1(n3297) mutant worms upon d cco-1 or e his-3 RNAi. Worms were collected for qRT-PCR analysis at L4 stage. Bars represent mRNA levels relative to N2 worms treated with empty vector with error bars indicating mean ± s.d. of three biological replicates, each with three technical replicates (*P < 0.05, **P < 0.01, ***P < 0.001; one-way ANOVA with Tukey’s post test)

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