Fig. 5
From: Type I interferon-mediated autoinflammation due to DNase II deficiency
Non-interferon signaling in patients with mutations in DNASE2, STING and TREX1, and in controls. a Multiplex cytokine analysis of serum from five patients (five samples) with loss-of-function mutations in TREX1, 7 patients (seven samples) with gain-of-function mutations in STING, FII:II-4 (two samples), F1:V-3 (seven samples), F1:V-1 (five samples) and six healthy controls (comprising three children, PHC, and three adults, HC). A pattern of enhanced expression of cytokine/chemokine proteins shared across patients mutated in STING and DNASE2 is indicated by the dotted lines, with genes ranked according to Spearman’s correlation. b Levels of TNFα, IL-1β and IL-6 protein in plasma from F1:V-1 and F1:V-3 sampled across 25 months. The dotted lines represent the cutoff for the normal range in controls for each cytokine
