Fig. 6
TBS increases cholinergic synaptic inputs in AD mice. a Experimental schedules (top) show that ΔG-rabies-ChR2 virus injection in the AD/NGIsTVA/G+ mice at 150 ± 5 days old of age resulted in AD/vChATsChR2+ mice. The mice were applied with 28-days TBS at 7 days after the virus injection. Electrophysiological recordings and staining (R/S) were performed immediately after TBS. A representative image indicates the ChR2-GFP expression in vChATs neurons of the AD/vChATsChR2+ mice. b Representative images reveal the ChATs-labeled terminals targeting at the individual dNGIs. A plot shows the actual (black circles) and the averaged numbers (red triangles) of terminals/10 cm dendrites (mean ± SEM, n = 5 mice/group, F 1.19 = 10.8, *p = 0.0051, two-way ANOVA)
