Nature Communications

Table 3 Grignard scope

From: Highly enantioselective catalytic synthesis of chiral pyridines


Entry	R′MgX	R	Product	Yield (%)^a	ee (%)^b
1	EtMgBr	Ph	2a	94	93
2	PrMgCl	Ph	5a	75	93
3	HexMgBr	Ph	5b	81	95
4	i-PentMgBr	Ph	5c	65	97
5	i-BuMgBr	Hexyl	5d	56	64
6^c	c-PentMgBr	Hexyl	5e	54	89
7	CH₂=CH(CH₂)₂MgBr	Hexyl	5f	91	93
8	CH₂=CH(CH₂)₃MgBr	Ph	5g	66	90
9	Ph(CH₂)₂MgBr	Hexyl	5 h	89	97
10^d	MeMgBr	Hexyl	5i	50	93
11^e	PhMgBr	Hexyl	5j	84	0

^aReported yields are for isolated products
^bDetermined by chiral HPLC
^c4. equiv. of Grignard was used
^dReaction was carried out at 0 °C for 5 h
^eLigand L10 was used (see Supplementary Table 1 for L10 structure)

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