Fig. 4
Impact of Vps34 inactivation on hepatic glucose production and glucose uptake in muscle in vivo. a Endogenous glucose production (EGP) in liver in hyperinsulinemic-euglycemic clamp experiments in WT (n = 5) and Vps34D761A/+ mice (n = 6) under NCD, and in WT (n = 7) and Vps34D761A/+ mice (n = 6) under HFD. Glucose kinetics are shown in Supplementary Table 3. Data represent mean ± SEM (non-parametric Mann–Whitney t-test). b 2-Deoxy-d-glucose (2-DG) uptake in muscle in hyperinsulinemic-euglycemic clamp experiments in WT (n = 3) and Vps34D761A/+ mice (n = 6) under NCD, and in WT (n = 5) and Vps34D761A/+ mice (n = 7) under HFD. Data represent mean ± SEM (non-parametric Mann–Whitney t-test). *p < 0.05, **p ≤ 0.01, ***p ≤ 0.001
