Table 1 Characteristics of DILI patients

From: The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

 

All patients

Hepatocellular injury

Cholestatic injury

Mixed injury

n

21

9

7

5

Age (years)

49.3 ± 19.6

49.7 ± 19

47.7 ± 18.1

51.8 ± 26.8

Gender (F/M)

10/11

5/4

3/4

2/3

ALT (U/L)

438.8 ± 428.7

163.1 ± 109.5

722.4 ± 528.8

314.0 ± 89.8

AST (U/L)

324.9 ± 393.7

123.7 ± 58.8

568.2 ± 514.9

168.4 ± 70.2

GGT (U/L)

386.5 ± 433.1

744.5 ± 646.2

38.9 ± 35.6

296.2 ± 268.4

ALP (U/L)

360.8 ± 419.2

655.6 ± 617.1

143.2 ± 72.2

339.8 ± 194.3

TBIL

7.5 ± 6.0

6.6 ± 5.4

8.4 ± 7.4

7.3 ± 4.8

Severity, n (%)

 Mild

6 (28.6)

3 (33.3)

2 (28.6)

1 (20)

 Moderate

11 (52.4)

3 (33.3)

5 (71.4)

3 (60)

 Severe

3 (14.3)

2 (22.2)

0 (0)

1 (20)

 Fatal

1 (4.8)

1 (11.1)

0 (0)

0 (0)

  1. ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma glutamyl transferase, TBIL total bilirubin
  2. Data are expressed as mean ± SD