Fig. 1 | Nature Communications

Fig. 1

From: Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population

Fig. 1

Schematic view of the study design for the common variant analysis. 'A' indicates the first method for ratio computation, where we  computed the associations between SNPs (within 100 Kb of the sentinel SNP from single-metabolite association analysis) and the ratio of the sentinel metabolite to all remaining 825 metabolites. 'B' indicates the second method for ratio computation, where for all SNPs for which two metabolites had been nominally associated in the discovery phase (p ≤ 10−4), but in opposite directions (opposite beta signs), we computed the association of the given SNP to the ratio of that pair of metabolites

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