Fig. 2

Comparing results from multiple studies of the same disease reveals patterns in disease-associated microbiome alterations. Heat maps showing log₁₀(q values) for each disease (KW test, Benjamini–Hochberg FDR correction). Rows include all genera which were significant in at least one data set within each disease, columns are data sets. q values are colored by direction of the effect, where red indicates higher mean abundance in disease patients and blue indicates higher mean abundance in controls. Opacity ranges from q = 0.05–1, where q values less than 0.05 are the most opaque and q values close to 1 are gray. White indicates that the genus was not present in that data set. Within each heat map, rows are ordered from most disease-associated (top) to most health-associated (bottom) (i.e., by the sum across rows of the log₁₀(q values), signed according to directionality of the effect). The extent of a disease-associated microbiome shift can be visualized by the number of rows in each disease heat map; the directionality of a shift can be seen in the ratio of red rows to blue rows within each disease. See Supplementary Fig. 2 for genus (row) labels