Table 1 Recurrently mutated genes in mouse and human ACP

From: Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Human ACP

Hesx1Cre/+;Ctnnb1lox(ex3)/+ tumours

Gene

cDNA change

Protein change

Variant classification

Gene

cDNA change

Protein change

Variant classification

ASCC2

c.1861G>A

p.D621N

Missense

Ascc2

c.1016+10G>A

NA

Splice region

DNAJC3

c.1243C>T

p.R415*

Nonsense

Dnajc3

c.1381G>T

p.G461*

Nonsense

KIF1C

c.2087G>A

p.R696Q

Missense

Kif1c

c.474G>T

p.L158F

Missense

PKD1L1

c.3862C>T

p.R1288C

Missense

Pkd1l1

c.55G>T

p.W19C

Missense

TGFBI

c.1286C>T

p.A429V

Missense

Tgfbi

c.662A>C

p.D221A

Missense

  1. *Nonsense mutation
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