Fig. 5
From: Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
Complex structures of the Smad4 and Smad3 MH1 domains with the GGCT site. a Schematic representation of the GC1 site. The GGCT DNA used for crystallization was TGCAGGCTAGCCTGCA and its location in the GC1 site is highlighted in dark brown. b Asymmetric unit of Smad4 complex with the GGCT motif. The ASU contains two Smad4 MH1 domains and one dsDNA. c Smad4 complex with the GGCT motif, as in Fig. 4c. Lys88 is displayed with two side chain orientations, as present in the different molecules of the ASU. d Intermolecular contacts for Smad3 complex with the GGCT motif, as in Fig. 4d. e Smad3 complex with the GGCT motif. The asymmetric unit of the complex contains two Smad3 MH1 domains and one dsDNA. f Smad3 complex with the GGCT motif, as in Fig. 4c. g Intermolecular contacts for Smad4 complex with the GGCT motif, as in Fig. 4d
