Fig. 6
From: The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission
σ1R activation decreases METH-induced conditioned place preference. a Experimental paradigm for conditioned place preference (CPP) is shown. b Dose-response experiment using 1, 2, and 4 mg/kg METH (n = 11, 12, 11 C57BL/6 mice, respectively) produced reproducible CPP for METH. 2 mg/kg METH showed the largest CPP on the post-conditioning test compared to saline (SAL)-treated mice (F (3,41) = 2.954, P = 0.0436; with Tukey’s test for multiple comparisons, *P < 0.05). Therefore, 2 mg/kg METH was used for all further CPP studies. c Neither 1, 2, nor 4 mg/kg PRE-084 (n = 4, 8, and 8 mice, respectively) showed CPP or conditioned place aversion compared to saline treatment (n = 8 mice). d Mice receiving 2 mg/kg METH (n = 12 mice) exhibited significant CPP compared to saline-treated animals (n = 12 mice). Treatment with 1, 2, and 4 mg/kg (n = 11 mice each) of PRE-084 before METH exposure decreased the CPP response, which was not significantly different from saline treatment (F (4,52) = 3.695, P = 0.0101, one-way ANOVA; Bonferroni’s test for multiple comparisons, P = 0.0388). Data is represented as mean ± SEM
