Fig. 5 | Nature Communications

Fig. 5

From: Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic

Fig. 5

Effects on proliferation of T-lymphocytes. The tricyclic antidepressants (clomipramine, desipramine, imipramine, trimipramine, and doxepin) reduced proliferation of T-cells markedly (p < 0.0001). Data were normalized to counts per minute (cpm) of activated control T-cells. Shown are data pooled from two independent experiments each performed in quadruplicates. Data are depicted as mean ± SEM. One-way ANOVA with Dunnett's multiple comparisons test as post hoc analysis compared to activated splenocytes. *p < 0.05; **p < 0.01; ****p < 0.0001

Back to article page