Fig. 3
From: Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Absence of Gal-3 leads to lower survival and increased fungal burden in experimental murine cryptococcosis. The survival rate (a) of Gal-3 KO mice (red line with circle) and WT mice (blue line with square) were verified after intratracheally infection with H99 yeast cells. b Colony-forming units (CFU) recovered from brain and lungs of WT (blue bars) and Gal-3 KO (red bars) mice were assessed after 3, 7, and 14 days after intratracheally infected with C. neoformans. The y-axis denotes CFU/ml/mg resulting from normalization of fungal burden to the weight of the organ fragment used to prepare the homogenate. Data are representative of three experiments, each performed with eight mice per group. The bars represent the mean ± SD of CFU obtained from triplicate samples in groups of eight animals. *p < 0.05, Student’s t-test, Gal-3 KO mice compared with WT mice
