Fig. 7
From: Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
A proposed model depicting the role of Polη O-GlcNAcylation in its removal after TLS. Upon UV or CDDP exposure, Polη is recruited to stalled replication forks and gets O-GlcNAcylated by OGT. Once Polη’s role in TLS is completed, O-GlcNAcylated Polη is ubiquitinated by CRL4CDT2 E3 ligase complex. The polyubiquitinated Polη is then recognized by p97-UFD-NPL4 complex, resulting in its dissociation from replication forks and degradation
