Fig. 3 | Nature Communications

Fig. 3

From: RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia

Fig. 3

DNA methylation defines an aggressive JMML subgroup with high risk of relapse. Kaplan–Meier curves showing the clinical outcome of JMML patients stratified for methylation subgroups. HM: red curve, IM: blue curve, and LM: green curve. At the bottom of each graph the numbers of individuals at risk (N) and the numbers of events (E) are summarized according to methylation group. The curve labels represent the estimates for 5-year overall survival a and 5-year cumulative incidence of relapse b and the 95% confidence interval of the estimate. a Overall survival (OS) from diagnosis for the entire validation cohort (n = 147). Statistical significance was tested using log-rank test. b Cumulative incidence of relapse (CIR) for all patients with complete mutation analysis, who received HSCT (n = 92) and who did not have a diagnosis of Noonan syndrome or CBL syndrome (please refer to Supplementary Tables 2 and 3, and to Supplementary Data 3 for further information on patient characteristics). Statistical significance was tested using Gray’s test

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