Fig. 2 | Nature Communications

Fig. 2

From: Identification and characterization of two functional variants in the human longevity gene FOXO3

Fig. 2

SRF binds to the longevity allele A but not to the major allele G of rs4946935. Nuclear extracts from Panc1 a and Jurkat b cells were submitted to EMSA with the indicated oligonucleotides. Supershift experiments were performed with antibodies as listed. The position of the supershifted complex is indicated by an arrow. One biological replicate of four is shown. Gt goat, IgG immunoglobulin G, NC nonspecific control (NC I: anti-STAT5A, rabbit; NC II: anti-PDX1, rabbit; NC III, anti-PDX1, goat); PDX1 pancreatic and duodenal homeobox 1, rb rabbit, SRF serum response factor

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