Table 1 Association statistics for the FOXO3 SNVs rs4946935 and rs12206094 in the whole German study population and centenarian subpopulation

From: Identification and characterization of two functional variants in the human longevity gene FOXO3

SNV

Study population

MAFa LLI

MAFa Controls

P CCA b

ORc

95% C.I.d

Whole study population

rs4946935

 

Total

0.349

0.304

0.003

1.228

1.072–1.406

 

Female

0.350

0.313

0.037

1.181

1.010–1.381

 

Male

0.347

0.278

0.022

1.375

1.046–1.808

rs12206094

 

Total

0.325

0.287

0.010

1.196

1.044–1.369

 

Female

0.322

0.291

0.068

1.157

0.989–1.353

 

Male

0.333

0.275

0.045

1.318

1.006–1.726

Centenarian subpopulation

rs4946935

 

Total

0.370

0.304

0.0003

1.345

1.147–1.577

 

Female

0.372

0.313

0.004

1.303

1.088–1.559

 

Male

0.360

0.278

0.032

1.458

1.032–2.060

rs12206094

 

Total

0.345

0.287

0.001

1.306

1.116–1.529

 

Female

0.342

0.291

0.011

1.261

1.055–1.508

 

Male

0.357

0.275

0.024

1.469

1.052–2.050

  1. Listed are allele frequencies, allelic P values, odds ratios, and the 95% confidence intervals for the whole study population and centenarian subpopulation (1109 LLI ≥ 95 years including 594 centenarians, 918 younger controls (age range: 60–75 years)). The statistics are listed for all individuals of the study populations as well as for males and females separately (males: 275 LLI ≥ 95 years including 119 centenarians, 237 younger controls; females: 834 LLI ≥ 95 years including 475 centenarians, 681 younger controls)
  2. a Minor allele frequency, MAF; the definition of the minor allele is based on controls; minor alleles are A for rs4946935 and T for rs12206094
  3. b Allelic P values, PCCA; calculated with chi-squared test with one degree of freedom
  4. c Odds ratio for longevity, OR; based on the minor allele in controls
  5. d 95% confidence interval, 95% C.I.; C.I. for the odds ratio