Table 1 Association statistics for the FOXO3 SNVs rs4946935 and rs12206094 in the whole German study population and centenarian subpopulation
From: Identification and characterization of two functional variants in the human longevity gene FOXO3
SNV | Study population | MAFa LLI | MAFa Controls | P CCA b | ORc | 95% C.I.d |
---|---|---|---|---|---|---|
Whole study population | ||||||
rs4946935 | ||||||
Total | 0.349 | 0.304 | 0.003 | 1.228 | 1.072–1.406 | |
Female | 0.350 | 0.313 | 0.037 | 1.181 | 1.010–1.381 | |
Male | 0.347 | 0.278 | 0.022 | 1.375 | 1.046–1.808 | |
rs12206094 | ||||||
Total | 0.325 | 0.287 | 0.010 | 1.196 | 1.044–1.369 | |
Female | 0.322 | 0.291 | 0.068 | 1.157 | 0.989–1.353 | |
Male | 0.333 | 0.275 | 0.045 | 1.318 | 1.006–1.726 | |
Centenarian subpopulation | ||||||
rs4946935 | ||||||
Total | 0.370 | 0.304 | 0.0003 | 1.345 | 1.147–1.577 | |
Female | 0.372 | 0.313 | 0.004 | 1.303 | 1.088–1.559 | |
Male | 0.360 | 0.278 | 0.032 | 1.458 | 1.032–2.060 | |
rs12206094 | ||||||
Total | 0.345 | 0.287 | 0.001 | 1.306 | 1.116–1.529 | |
Female | 0.342 | 0.291 | 0.011 | 1.261 | 1.055–1.508 | |
Male | 0.357 | 0.275 | 0.024 | 1.469 | 1.052–2.050 |