Fig. 1
From: RETRACTED ARTICLE: REST regulates the cell cycle for cardiac development and regeneration
Rest is required for myocardial development and cardiomyocyte proliferation. a, b Immunostaining and western blot analyses showing the efficient deletion of Rest in cardiomyocytes in TnTCre;RestGT/GT (RestmKO) hearts. Controls were RestGT/GT mice. c A summarizing graph of the distribution and number of embryos at different stages indicates death of Restmko embryos between E12.5 and E16.5. d, e H&E-stained sections of E10.5 and E12.5 hearts indicate thin ventricular wall resulting from Rest deletion. f Quantitative immunostaining of cell cycle markers showing reduced proliferation of RestmKO cardiomyocytes. n = 4/group, mean ± s.d., *p < 0.05 by unpaired two-tailed Student’s t test. Scale bars = 40 µm
