Fig. 7
From: RETRACTED ARTICLE: REST regulates the cell cycle for cardiac development and regeneration
Rest is required for regeneration of injured neonatal hearts. a, b Quantitative Masson’s trichrome staining shows increased cardiac fibrosis in mice with induced myocardial Rest deletion at P3 and injured by apex ablation at P4, n = 5–8/group. Scale bar = 100 μm. c, d Echocardiography indicating reduced cardiac function of myocardial Rest null mice after injury, n = 6–8/group. e–g Quantitative immunofluorescence (n = 4/group) showing decreased EdU+ cardiomyocytes in regenerating hearts in mice with Rest deletion. Scale bar = 40 μm. Mean ± s.d. p < 0.05 by two-way ANOVA followed by Sidak’s test in b–d; unpaired two-tailed Student’s t test in f, g
