Table 3 Anti-proliferative effects of corin and related compounds in cutaneous squamous cell carcinoma cells after 72 h treatment
From: Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
IC50 ± SE (µM) | ||
|---|---|---|
Compound | IC1 cells | MET1 cells |
Corin | 0.041 ± 0.011 | 0.006 ± 0.001 |
MS-275 | 1.03 ± 0.07 | 0.144 ± 0.014 |
Compound 9 | 0.397 ± 0.042 | 0.094 ± 0.009 |
Compound 7 | 0.448 ± 0.187 | 0.171 ± 0.036 |
GSK2879552 | 2.91 ± 0.71 | 0.211 ± 0.042 |
MS-275 + Compound 7 | 0.249 ± 0.075 | 0.011 ± 0.001 |
MS-275 + GSK2879552 | 0.275 ± 0.027 | 0.042 ± 0.007 |
Tranylcypromine | 3.94 ± 0.98 | 2.03 ± 0.54 |
Pargyline | > 270 | > 270 |
