Fig. 6
From: Voltage-gated sodium channels assemble and gate as dimers
Example of biophysical coupling between R1629Q and R878C mutants when co-transfected in HEK293 cells. a Steady-state inactivation. b Time constants of inactivation measured at the listed voltages. Bottom part shows representative examples of the fit. c Voltage-dependent activation obtained using the conductance equation. d Current–voltage relationship, I/V curves. Left column without difopein, Right column in presence of difopein. Importantly, in presence of difopein we see uncoupling of the steady-state inactivation, time constants of inactivation and voltage-dependent activation. Data are presented as mean ± SEM ***p < 0.001
