Fig. 2 | Nature Communications

Fig. 2

From: NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease

Fig. 2

Myeloid-specific inflammasome activation generates systemic inflammation. Spontaneous inflammatory disease manifesting in the tibiotarsal joints a–c, the duodenum d, and kidney e of iOvaFla; LysM-Cre+/− mice aged 10–14 weeks. a 14 week iOvaFla; LysM-Cre+/− mice are runted and display joint disease compared to age and sex-matched iOvaFla; LysM-Cre– /− mice. b Weight and tibiotarsal joint swelling as the mice age (n = 4–5 biological replicates per genotype). c–e Histology images showing c tibiotarsal joint, d duodenum, and e kidney damage in 10 week iOvaFla; LysM-Cre+/− mice compared to Nlrc4 −/−; iOvaFla; LysM-Cre+/− mice (representative images from three biological replicates; tibiotarsal joint at magnification ×40 and scale bar is 500 microns; duodenum at magnification ×600 and scale bar is 20 microns; kidney at magnification ×400 and scale bar is 20 microns). Data in c–e are representative of two independent experiments. Error bars are s.d.

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