Fig. 4
From: LARP7 family proteins have conserved function in telomerase assembly
lar7Δ causes exosomal degradation of TER1. a Expression of TER1 mRNA quantified using RT-qPCR and normalised to actin. Expression is shown relative to wild-type cells without the ter1 overexpression promoter. rrp6Δ rescues the reduced expression seen in lar7Δ cells. Data represented as a mean of four independent experiments. Error bars show standard deviation. Significantly less TER1 was detected in lar7Δ vs WT ter1 overexpression promoter cells (p = 0.0063) and lar7Δ vs. lar7Δrrp6Δ ter1 overexpression promoter (p = 0.0242, unpaired t test * at p > 0.05 and ** at p < 0.01). b Telomere southern blot. The rescued expression of TER1 in lar7Δrrp6Δ cells shown in a did not rescue short telomere phenotype (lanes 4 and 8)
