Fig. 3 | Nature Communications

Fig. 3

From: Promoter-enhancer interactions identified from Hi-C data using probabilistic models and hierarchical topological domains

Fig. 3

Chromatin marks surrounding predicted enhancer regions. Chromatin marks at 4 Mb windows centered around 17,788 putative enhancer regions, predicted using PSYCHIC (FDR < 1e-2) for adult mouse cortex Hi-C data25. Shown are typical enhancer marks (H3K27ac, H3K4me1), along with PolII and CTCF ChIP-seq, chromHMM classifications, H3K27me3, and DNaseI hypersensitivity assays. Blue lines mark the average signal over the predicted enhancer Hi-C bins. Black dotted lines mark the signal averaged over a random set of genomic loci, sampled in 2 Mb windows around promoters. The statistical significance of each plot (p value) is calculated by comparing the average signal at putative enhancers with their >500 Kb surrounding

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