Fig. 2
From: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
Dysregulated OCP and chondrocyte homeostasis caused by Senp6 loss. a The growth plate of P0 Prx1-Cre;Senp6f/f mice showed an enhanced apoptosis (upper panel) and decreased proliferation (lower panel). The red boxed regions were enlarged and are shown in the lower-right corner of each image. Scale bars = 100 μm for growth plate and 50 μm for the enlarged red boxes. Representative images are on the left and quantifications on the right (n = 3, error bars = standard deviation, *p < 0.05, Student’s t-test). b Prx1-Cre;Senp6f/f bone marrow had a decreased number of CFU-F and CFU-O (n = 3). c Rib chondrocytes cultured from Dermo1-Cre;Senp6f/f mouse showed an augmented cell senescence (SA-β-gal staining); representative images are at the left and quantification at the right. Scale bar = 50 μm; n = 3, error bars = standard deviation; *p < 0.05 relative to Senp6f/f (control), Student’s t-test
