Fig. 5
Particle elasticity regulates in vivo tumor uptake. a In vivo NIR fluorescent images of mice at post-6h and -48h after i.v. administration of DiR-labeled NLP-45KPa, NLG-1.6MPa, NLG-13.8MPa, and NLG-19MPa (n = 10 for each group). b In vivo tumor accumulation of synthesized NLP-45KPa and NLGs was quantified by fluorescent intensity. c Ex vivo NIR fluorescent images of excised tumors at post 48 h. d The biodistribution of NLP-45KPa and NLGs in organs (liver, spleen, lung, kidney, heart, and brain) and tumors was quantified by their fluorescent intensity at post-48h (n = 10 for each group). e Uptake of NLP-45KPa and NLGs by mouse leukocytes was quantified by flow cytometry (n = 8–10 for each group). ns not significant, *P < 0.05, **P < 0.01, ***P < 0.001. The mean values and error bars are defined as mean and S.D., respectively
