Fig. 7
From: HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
HOXC5 suppresses hTERT expression and inhibits cancer cell growth. Representative images (a) and quantification (b) of in vitro colony formation assay in PC-3 cells expressing GFP, mir-615-3p, HOXC5 or both HOXC5 and mir-615-3p. Tumor growth curve (c) representing images (d), and tumor weight (e) showed growth of xenograft tumors in NSG mice injected with PC-3 cells expressing GFP, mir-615-3p, HOXC5 or both HOXC5 and mir-615-3p in vivo. Significance was determined by t test. *P < 0.05. Scatterplots showing Spearman correlation between hTERT and HOXC5 (f, i); miR-615-3p and hTERT (g, j); HOXC5 and miR-615-3p (h, k) in THYM (top) and TGCT (bottom) cancer samples. Red line indicates the linear fit with 95% confidence interval in shaded gray. All values are in RSEM log2 units. TGCT testicular germ cell tumor; THYM thymoma
