Fig. 6
From: Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways
Mathematical model: analysis of the effect of IFNβ pre-stimulation on responses to poly(I:C). a Network diagram. The components of the model which do not influence other components are listed next to the diagram. Blue arrow-headed lines = activation, red hammer-headed lines = inhibition, green arrow-headed lines = positive regulation of transcription. b, c The three-day long stochastic simulations are preceded by 3 × 106 s (~35 days) of stochastic equilibration phase (not shown) rendering different values of model variables at time = 0 for the 5 trajectories shown in each panel. b After 2 days of quiescence, WT MEFs were stimulated with 1 μg/ml poly(I:C) for 1 day. c After 1 day of quiescence, WT MEFs were prestimulated with 1000 U/ml IFNβ for 1 day, followed by 1 day stimulation with 1 μg/ml poly(I:C)
