Fig. 8
From: Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways
Apoptotic cell fraction in response to LPS, TNFα, poly(I:C) or IFNβ. Bars show mean fractions of early apoptotic (pink) and late apoptotic/dead cells (purple), estimated by Annexin V/PI staining (bars represent means ± s.d., n ≥ 3, data for all replicates are given in the Supplementary Data 14). See Supplementary Fig. 8 for density plots of Annexin V/PI staining. a Fraction of apoptotic WT MEFs in response to 1 μg/ml LPS, 10 ng/ml TNFα or 1 μg/ml poly(I:C) after 24 h of treatment. b Fraction of apoptotic RelA–/– MEFs in response to 24-hr stimulation with 10 ng/ml TNFα or 1 μg/ml poly(I:C). c Fraction of apoptotic WT MEFs in response to 24-hr treatment with 1 μg/ml poly(I:C) following 24 h of quiescence or 1000 U/ml IFNβ pre-stimulation. d Fraction of apoptotic Stat1–/– MEFs in response to 24 h of 1000 U/ml IFNβ stimulation, 1 μg/ml poly(I:C) 24 h treatment, or response to 24 h treatment with 1 μg/ml poly(I:C) after 24 h of 1000 U/ml IFNβ pre-stimulation. e Apoptotic fraction time course for WT MEFs in response to 1 μg/ml poly(I:C). f Apoptotic fraction time course for WT MEFs in response to 1 μg/ml poly(I:C) following 24 h of 1000 U/ml IFNβ pre-stimulation
