Fig. 5
From: Lack of beta-arrestin signaling in the absence of active G proteins
pERK1/2 profiles of ligand-activated β2AR, AT1R, and V2R in WT and Δβarr1/2 cells. a–c Temporal pattern of ERK1/2 phosphorylation and total ERK1/2 by β2AR in wild-type (a), Δβarr1/2 (b), and ΔGs (c) HEK293 cells treated with the indicated ligands. d–f Temporal pattern of ERK1/2 phosphorylation and total ERK1/2 by ligand-activated AT1R in wild-type (d), Δβarr1/2 (e), and ΔGsix cells+PTX (f). g–i Kinetic pERK1/2 and total ERK1/2 profile of V2R in wild-type (g), Δβarr1/2 (h), and ΔGsix cells+PTX (i). Data are mean +/± s.e.m. of three (g, h, i), four (a–d, f) and five (e) experiments each performed in triplicate
