Table 3 Several leukocyte telomere length associated SNPs are also associated with intrinsic epigenetic age acceleration in blood
From: GWAS of epigenetic aging rates in blood reveals a critical role for TERT
Study | Chr | Gene | SNP | A1 | MAF | Effect size (β) | Meta P-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
LTL | IEAA | EEAA | LTL | IEAA | EEAA | ||||||
II | 2 | ACYP2 | rs11125529 | A | 0.14 | 0.06 | −0.06 | −0.15 | 4.5 × 10−8 | 0.5 | 2.5 × 10−1 |
III | 3 | PXK | rs6772228 | A | 0.06 | −120 | 0.26 | 0.20 | 3.9 × 10−10 | 1.3 × 10−1 | 3.7 × 10−1 |
II | 3 | TERC | rs10936599 | T | 0.24 | −0.10 | 0.04 | −0.07 | 2.5 × 10−31 | 0.7 | 4.7 × 10−1 |
III | 3 | rs1317082 | G | 0.23 | −77 | 0.04 | −0.08 | 1.3 × 10−19 | 0.7 | 4.6 × 10−1 | |
II | 4 | NAF1 | rs7675998 | A | 0.22 | −0.07 | −0.07 | 0.04 | 4.4 × 10−16 | 4.4 × 10−1 | 0.7 |
III | 5 | TERT | rs7726159 | A | 0.33 | 73 | 0.67 | 0.27 | 4.7 × 10−17 | 9.5 × 10−12 | 6.4 × 10−2 |
I | 5 | rs7705526 | A | 0.33 | 0.51 | 0.61 | 0.18 | 2.3 × 10−14 | 1.0 × 10−11 | 1.9 × 10−1 | |
II | 5 | rs2736100 | C | 0.50 | 0.08 | 0.49 | 0.19 | 4.4 × 10−19 | 2.7 × 10−11 | 8.2 × 10−2 | |
III | 10 | OBFC1 | rs2487999 | T | 0.14 | 100 | 0.22 | 0.36 | 4.2 × 10−14 | 3.7 × 10–2 | 8.8 × 10–3 |
II | 10 | rs9420907 | C | 0.20 | 0.07 | 0.26 | 0.20 | 6.9 × 10−11 | 4.1 × 10–3 | 9.9 × 10−2 | |
II | 16 | MPHOSPH6 | rs2967374 | A | 0.22 | 0.05 | 0.23 | 0.12 | 2.7 × 10−7 | 7.8 × 10–3 | 2.9 × 10−1 |
II | 19 | ZNF208 | rs8105767 | G | 0.32 | 0.05 | −0.05 | −0.13 | 1.1 × 10−9 | 0.5 | 1.7 × 10−1 |
III | 20 | BCL2L1 | rs6060627 | T | 0.34 | 36 | −0.13 | 0.11 | 6.5 × 10−7 | 7.7 × 10−2 | 2.6 × 10−1 |
II | 20 | RTEL1 | rs755017 | G | 0.15 | 0.06 | 0.03 | −0.08 | 6.7 × 10−9 | 0.8 | 0.5 |
