Fig. 3 | Nature Communications

Fig. 3

From: Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus

Fig. 3

Greater dorsal-ventral differentiation of DNA methylation in enriched environment. a At DMRs hypomethylated in dDG, dorsal DNA methylation is lower in EE compared with SH reared animals at CG, CA and CT sites (p < 0.05, ANOVA). Ventral methylation is unaffected. b Median difference in mCG between EE and SH samples across all genomic bins (1 kbp) stratified by regional (dorsal-ventral) difference in mCG shows a strong effect in the dorsal, but not ventral, DG. c Mean mCG profile centered on dorsal DMRs in DG, as well as in fetal and 1 week old frontal cortex21. d Genes that are up-regulated in EE are also enriched in dDG

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