Fig. 5 | Nature Communications

Fig. 5

From: Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

Fig. 5

Characterization of LMRs and mCpG in heart failure. a Analysis of LMRs with differential mCpG between adult non-failing and failing cardiac myocytes. b, c Profiles of mCpG (b) and histone marks (c) at DM-LMRs that are hypomethylated or hypermethylated between failing and non-failing cardiac myocytes. d Significantly enriched transcription factor (TF) binding motifs in hypomethylated DM-LMRs. Hypermethylated DM-LMRs (group II) did not show significant enrichment for TF motifs. Given are HOMER transcription factor enrichment p-values. e, f Next gUMR mCpG level (e) and relative gene expression of adjacent genes (f) (mean ± SEM). Figures show data from n biological replicates: mCpG, n = 3–5; H3K27ac, H3K4me1, n = 3; RNA, n = 3–4

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