Fig. 6
Transcriptional decomposition across 76 human cell types. a–c Heat maps depicting pairwise similarities of the PD (a), PI (b) components and EP interactions (c) across cell types. All similarity scores were calculated between cell types using 1–L1 norm on binary data sets based on the sign of the PD, PI components or the presence/absence of EP interactions. Cell-type ordering is fixed according to the results of a hierarchical clustering (complete linkage) of the raw expression data. d Predicted probability of EP interactions averaged across groups of cells and CHiCAGO score of interaction based on GM12878 capture HiC data. GENCODE v24 transcripts, FANTOM5 enhancers and the average PD and PI component across blood cells are displayed below
