Fig. 5 | Nature Communications

Fig. 5

From: Sheep genome functional annotation reveals proximal regulatory elements contributed to the evolution of modern breeds

Fig. 5

Candidate causal missense mutation in FBXL3. a FBXL3 gene representation in human hg19 coordinates chr13:77579389-77601337. b Multiple sequence alignment of SNP across representative vertebrates. c Allele frequency of the G (reference) or A (alternative) allele in domestic sheep (O. aries) (n = 67) or mouflon (O. orientalis) (n = 17). d FBXL3 amino acid sequence with the substitution at residue 182 highlighted in red. Residue 358 (green) is associated with the mouse After hour (Afh) phenotype residue 364 with the overtime phenotype (Ovt)

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