Fig. 7 | Nature Communications

Fig. 7

From: BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1

Fig. 7

Model for the regulation of BMI1 on androgen receptor independently of PRC1. Besides its PRC1-dependent role (canonical pathway) as a transcriptional repressor, BMI1 also has a PRC1-independent role (noncanonical pathway) as a transcriptional activator: BMI1 stabilizes AR and activates AR-signaling pathway via competitively inhibiting MDM2-induced ubiquitination and degradation of AR in PCa

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