Fig. 6

GSK3β deletion in CD4⁺ T cells improves CD4⁺ T cell survival and prevents colitis. a Tamoxifen treatment of Gimap5^sph/sph; Gsk3b^fl/fl; Cd4cre-ert2 mice starting at 3 weeks of age selectively rescues splenic CD4⁺ T cell survival, b while maintaining overall CD4⁺ T cell quiescence. Reduced colitis in Gimap5^sph/sph; Gsk3b^fl/fl; Cd4cre-ert2 mice treated with tamoxifen as determined by disease scores (c) based on histology (d). Data represent mean values ± SEM from at least 6 mice per group at 8 weeks of age; histology is a representative depiction of disease severity. Scale bar is 50 μm. Statistical significance is determined by ANOVA followed by Sidak’s multiple comparisons test