Fig. 1 | Nature Communications

Fig. 1

From: Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties

Fig. 1

Location of missense mutations in the GluN2B subunit. a Homology hybrid model of the human tetrameric GluN1–GluN2B receptor using the rat (PDB: 4PE5) and frog (PDB: 4TLL, 4TLM) crystal structures as templates (orange: GluN1, blue: GluN2B). The amino terminal domain (ATD), ligand binding domain (LBD) and transmembrane domain (TMD) of the subunits are shown in ribbon format with the residues selected for study in green in stick format. b C461 is located in the S1 region of the LBD, proximal to the glutamate binding site with bound glutamate (yellow). c Glutamate at the orthosteric binding site (position taken from rat NMDAR structure; PDB: 4PE5). d P553 is located in pre-M1 in close proximity to M3. e N615 is located at the beginning of the M2–M3 linker and V618 is in the M2–M3 linker, its side-chain faces away from the channel pore

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