Fig. 8 | Nature Communications

Fig. 8

From: Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties

Fig. 8

Memantine inhibition of NMDAR-mediated EPSCs. Synaptic currents were recorded in 0 Mg2+, in the absence and presence of memantine (30 μM for GluN2BWT and GluN2BN615I; and 300 μM for GluN2BV618G) in hippocampal neurons 13–15 DIV expressing GluN2BWT (a, b), GluN2BN615I (c, d) and GluN2BV618G (e, f). Bar graphs report the percentage inhibition of mean peak EPSC amplitudes, one-way ANOVA p > 0.05 (g), and the area under the evoked EPSCs (h). Calibration in a applies to b–f

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