Table 1 Novel pancreatic cancer susceptibility loci
From: Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
Chra SNP Positionb gene | Effect allele (minor)/reference allele | Statistic | PanScan I/II 3535 cases and 3642 controls | PanScan III 1582 cases and 5203 controls | PanC4 3933 cases and 3651 controls | ALL GWAS 9040 cases and 12,496 controls | PANDoRA 2497 cases and 4611 controls | GWAS+PANDoRa 11,537 cases and 17,107 controls |
|---|---|---|---|---|---|---|---|---|
1p36.33 rs13303010 894,573 NOC2L | G/A | MAFc cases;controls | 0.14; 0.13 | 0.12; 0.10 | 0.13; 0.11 | 0.14; 0.10 | – | |
Infod | 0.42 | g | g | g | – | |||
OR (CI) | 1.15 (1.01–1.26) | 1.22 (1.09–1.33) | 1.16 (1.07–1.24) | 1.20 (1.12–1.29) | 1.45 (1.33–1.57) | 1.26 (1.19–1.35) | ||
P value | 3.64 × 10−2 | 1.48 × 10−3 | 9.54 × 10−4 | 7.30 × 10−7 | 6.00 × 10−10 | 8.36 × 10−14 | ||
Heterogeneity P valuee | 6.49 × 10−1 | 4.57 × 10−2 | ||||||
7p12 rs73,328,514 47488569 TNS3 | T/A | MAF cases; controls | 0.09; 0.11 | 0.10; 0.12 | 0.10; 0.12 | 0.10; 0.11 | – | |
Info | 0.93 | 0.97 | 0.97 | g | – | |||
OR (CI) | 0.80 (0.71–0.89) | 0.88 (0.76–1.02) | 0.82 (0.74–0.92) | 0.83 (0.77–0.88) | 0.94 (0.83–1.06) | 0.85 (0.80–0.90) | ||
P value | 8.38 × 10−5 | 9.31 × 10−2 | 3.61 × 10−4 | 4.35 × 10−8 | 3.08 × 10−1 | 1.35 × 10−7 | ||
Heterogeneity P value | 5.98 × 10−1 | 2.35 × 10−1 | ||||||
8q21.11 rs2941471 76,470,404 HNF4G | G/A | MAF cases; controls | 0.40; 0.43 | 0.41; 0.42 | 0.41; 0.43 | 0.40; 0.43 | ||
Info | 1.0 | 1.0 | 1.0 | g | ||||
OR (CI) | 0.87 (0.79–0.94) | 0.91 (0.80–1.01) | 0.89 (0.82–0.96) | 0.89 (0.86–0.94) | 0.87 (0.79–0.94) | 0.89 (0.85–0.93) | ||
P value | 2.39 × 10−4 | 8.30 × 10−2 | 2.19 × 10−3 | 4.73 × 10−7 | 2.42 × 10−4 | 6.60 × 10−10 | ||
Heterogeneity P value | 7.73 × 10−1 | 7.87 × 10−1 | ||||||
17q12 rs4795218 36,078,510 HNF1B | A/G | MAF cases; controls | 0.20; 0.23 | 0.22; 0.23 | 0.21; 0.23 | 0.21; 0.23 | ||
Info | 0.96 | 0.96 | 0.95 | g | ||||
OR (CI) | 0.87 (0.80–0.95) | 0.88 (0.78–0.98) | 0.88 (0.81–0.95) | 0.88 (0.82–0.93) | 0.90 (0.82–0.98) | 0.88 (0.84–0.92) | ||
P value | 1.12 × 10−3 | 2.29 × 10−2 | 1.11 × 10−3 | 2.73 × 10−7 | 1.38 × 10−2 | 1.32 × 10−8 | ||
Heterogeneity P value | 9.96 × 10−1 | 9.78 × 10−1 | ||||||
18q21.32 rs1517037 56,878,274 GRP | T/C | MAF cases; controls | 0.16; 0.19 | 0.17; 0.19 | 0.17; 0.18 | 0.17; 0.19 | ||
Info | g | g | g | g | – | |||
OR (CI) | 0.82 (0.75–0.89) | 0.92 (0.82–1.04) | 0.90 (0.83–0.98) | 0.87 (0.82–0.93) | 0.87 (0.79–0.97) | 0.86 (0.80–0.91) | ||
P value | 7.56 × 10−6 | 1.90 × 10−1 | 1.64 × 10−2 | 8.81 × 10−7 | 1.17 × 10−2 | 3.28 × 10−8 | ||
Heterogeneity P value | 1.87 × 10-1 | 7.73 × 10-2 | 1.03 × 10-1 |
