Fig. 9 | Nature Communications

Fig. 9

From: Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

Fig. 9

Schematic representation of epigenetic memory of Fgf21. Ligand-activated PPARα induces DNA demethylation of Fgf21 in the postnatal mouse liver; DNA methylation status of Fgf21, once established in early life, persists into adulthood, as an epigenetic memory. In adulthood, DNA methylation status determines the magnitude of Fgf21 expression response to environmental cues. This may lead to the reduction of body weight and adipose tissue mass during HFD feeding in adulthood

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