Fig. 6
From: A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
HERA score correlates with in vivo serum half-life in hFcRn transgenic mice. a HERA score for the WT and the Fc-engineered hIgG1 variants were calculated from the data shown in Fig. 5e, f. b, c Log-linear changes in the serum concentration of hIgG1 WT (black), YTE (blue), LS (green), KF (brown) and YTE/KF (red) in hFcRn transgenic mice and WT mice, respectively. The antibodies were administrated as a single i.v. injection to 5 mice per group. Correlations of the derived HERA scores with serum half-life values of hIgG1 variants obtained from d hFcRn transgenic (r = 0.9892, p < 0.0014) and e WT mice (r = 0.669, p < 0.2169). The data are represented as mean ± s.d.
