Table 2 Serum half-life data in WT and humanized FcRn mice
From: A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
IgG1 variants | IgG1 specificity | Route | Dose (mg/kg) | Half-life (days) (n = 5) | ±s.d. (days) | Mouse strains |
|---|---|---|---|---|---|---|
WT | 8.4 | 2.5 | Tg32 hemizygous mice | |||
YTE | 12.6 | 1.2 | ||||
LS | anti-NIP | IV | 5 | 11.2 | 2.2 | |
KF | 7.6 | 1.0 | ||||
YTE/KF | 3.3 | 0.3 | Tg32 homozygous mice | |||
WT | 4.9 | 0.4 | WT mice | |||
YTE | 3.6 | 0.6 | ||||
LS | anti-NIP | IV | 5 | 4.6 | 1.2 | |
KF | <2.0 | |||||
YTE/KF | <2.0 |
