Fig. 5
From: Structural basis for amino acid transport by the CAT family of SLC7 transporters
Structural basis for isoform difference between CAT-2A and -2B. a Zoomed-in view of the cytoplasmic region of the transporter, highlighting the interactions between TM6B, TM8 and the lateral helix. A sequence alignment of TM8 highlighting the difference (*) between CAT-2A and CAT-1, -2B and -3 is shown. b Representative IC50 curves determined for l-Ala binding to either the WT or R334E variant of GkApcT using electrogenic accumulation assays. IC50 values were calculated from three independent replicates
