Fig. 7
From: SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
Specific HIF-2α ablation in EC abolishes in vivo SOD3 effects. a, b Growth kinetics of Ad-C- or Ad-mSOD3-injected LLC tumors grafted in control (Cre−; a) or HIF-2αEC-KO mice (b). c, d Images of lectin-FITC-perfused (green), CD31-stained (red) vessels in tumors resected at day 18 (≤1 cm3) from control and HIF-2αEC-KO mice. e–i Vessel density (e), mean area (f), length (g), diameter (h), and branching (i) determined by CD31+ staining in tumors from a, b (n ≥ 25 fields/condition). j VEC mRNA levels, normalized to those of CD31, in tumors in a, b. k VEC-stained area as a percentage of VEC staining in CD31+ structures in images of tumors in a, b (see also Supplementary Fig. 10c–f); n = 10–20 images/group. *p < 0.05; **p < 0.01; ***p < 0.001; two-tailed Student’s t-test. Bar, 50 μm
