Fig. 8
From: SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
Coregulation of SOD3, VEC, and HIF-2α in primary CRC tumors. a, b Scatter plots showing individual data points and mean for SOD3 (a) and VEC (b) mRNA levels in non-tumor (C; n = 13) and CRC samples (CRC; n = 102). c Correlation of SOD3 and VEC mRNA levels in the CRC cohort. d, e Scatter plots as above for SOD3 (d) and VEC (e) mRNA levels in a validation cohort of 19 non-tumor and 87 stage III CRC samples. f Correlation of SOD3 and VEC mRNA levels in the CRC validation cohort. g TMA samples stained for SOD3 and HIF-2α, representative of low (#6) and high (#61) SOD3 levels. h, i Correlation of estimated H-scores for SOD3 and HIF-2α in stromal (h) and tumor (i) compartments. j Representative images from two tumor samples stained for CD34 (red), SOD3 (green), and HIF-2α (blue); the three-color merge is shown; nuclei were counterstained with DAPI (see Supplementary Fig. 11 for single-color images). White lines in the DAPI panel contour CD34-stained areas. c, f, h, i Spearman’s rank correlation test; a, b, d, e *p < 0.05, two-tailed Student’s t-test. Bar, 50 μm (g) and 20 μm (j)
