Fig. 2
Proteomic features of the diffuse-type gastric cancer. a Top ranked pathways that are significantly altered in tumors as compared with nearby tissues. b Significantly decreased gastric function proteins and gastric mucosa signature proteins in tumors and nearby tissues. The y-axis represents log10 (FOT) +5. *P < 0.05, **P < 0.01, *** P < 0.001 (Wilcoxon rank-sum test), ΔInsufficient sample size. c Box plots of log10 transformed T/N ratios of stomach-specific and not stomach-specific proteins; whiskers show the 1.5-fold IQR, P-value was calculated by Wilcoxon rank-sum test. d Common proteins up-regulated in majority of tumors that were classified in the four functional categories. (% in parenthesis denotes percentage of tumor samples that exhibit >3-fold change in 84 patients). e Altered proteins in the WNT, NOTCH, TGF, and INF pathways. Differentially expressed proteins in tumors (T/N >3) were boxed with red color. The number in parenthesis is the percentage of samples with overexpression when the protein was detected
