Fig. 4

Correlation of genomic mutations and protein expressions. a Differentially mutated genes and their pathways in PX1–3, *P < 0.05, **P < 0.01 (Fisher’s exact test). b Protein expression status of selected mutated genes. c Differential protein expression of mutated genes in the major cancer driver pathways. The left panel summarizes the correlation of altered protein expression and gene mutations of selected proteins in major oncogenic and tumor suppressive pathways; numbers in parenthesis represent number of patients that differential protein expression were detected, number of mutations detected, and number of cases where both were detected, respectively. Right panel shows differential protein expression and gene mutations in each patient. Large dots depict changes in protein expression, and small dots depict a variety of gene mutations. d Altered expression of tumor proteins associated with CDH1 mutations. Boxplots show protein expression levels of CDH1-mutated and CDH1-wild-type patients (*P < 0.05; **P < 0.01; ***P < 0.001, Wilcoxon rank-sum test). Whiskers show the 1.5-fold IQR