Fig. 5

Nominating potential druggable proteins for DGC. a The association between protein expression (T/N ratio) and overall survival of genomic data discovered drug targets. The ln (Hazard ratio) (x-axis) and log₁₀(P-value) (y-axis) were calculated from Cox proportional hazards regression analysis. Ln (Hazard ratio) >4 or <−4 were plotted with 4 or −4. Large dots depict proteins overexpressed in tumors, and small dots depict proteins that are not overexpressed in tumors. b The association between protein expression (T/N ratio) and overall survival of proteomic data discovered drug targets. A list of 23 proteins overexpressed in tumors with log-rank P-value < 0.05 and ln (hazard ratio) >0 is included in the box on the right. c The association between protein expression of CD300A, CYBA and IDO1 and overall survival (Kaplan–Meier analysis, P-value from log-rank test, high means T/N >median value). d Cellular localization and signaling pathways of nominated drug target candidates. The nominated druggable protein candidates are depicted in red